A 67-year-old man was reported with persistently elevated serum level of prostate-specific antigen (PSA). The patient was reported with elevated serum level of PSA and no evidence of tumor.

However, his father died of prostate cancer and sister with breast cancer. Pathological examination of the tissue revealed a tiny focus of adenocarcinoma (Gleason score, 6 out of 10 [grade 3 plus grade 3]) Physical examination Nontender and smooth prostate gland (45 ml in volume) without palpable nodules Bone scan for cancer was indeterminate Computed tomography (CT) of the abdomen and pelvis showed hyperdense lesions in the left acetabulum, the sacrum, the third lumbar vertebral body on the left No metastasis detected on magnetic resonance imaging (MRI), radiographs and CT Laboratory examinations Platelet count was 112,000 per cubic millimeter (reference range, 150,000 to 450,000) The blood level…