This engaging podcast series features leading neurologists and endocrinologists dissecting the multifaceted mechanisms driving diabetic peripheral neuropathy (DPN)—from hyperglycemia-induced oxidative stress and mitochondrial dysfunction to microvascular damage, neuroinflammation, and aberrant neuronal signaling pathways. Experts review the spectrum of DPN phenotypes, from small-fiber sensory loss to motor involvement, and discuss validated diagnostic tools, including skin biopsy, corneal confocal microscopy, and quantitative sensory testing.

The series also covers emerging therapies beyond glycemic control, such as sodium channel blockers, alpha-lipoic acid, and anti-inflammatory agents, alongside strategies for pain management and lifestyle interventions to slow progression. Clinical pearls emphasize early screening in high-risk diabetes patients and multidisciplinary care to mitigate…