Despite significant advances in the development of therapies targeting familial frontotemporal dementia (f-FTD) , a common form of early-onset dementia, research on accurate prediction of the onset of its symptoms in pre-symptomatic familial frontotemporal dementia (f-FTD) mutation carriers is lacking . In a landmark study, scientists have found that brain atrophy and plasma neurofilament light chain (NfL) elevations are measurable years prior to the onset of symptoms .
Study details Sample: Experimental group – 796 f-FTD carriers; Control group – 412 noncarriers Method: Multimodal models for f-FTD disease progression in C9orf72, GRN, and MAPT mutation carriers; models combined and harmonized the clinical, neuroimaging, and fluid biomarkers in the f-FTD carriers The researchers found that as individuals transitioned from asymptomatic to symptomatic disease, the temporal ordering of…
