Cystic fibrosis (CF), once considered a pediatric condition, now affects a growing adult population thanks to advances in care and the advent of CFTR modulators , which have extended median life expectancy to about 61 years. These therapies have also contributed to a doubling of pregnancies among women with CF , underscoring the need for comprehensive reproductive counseling . For those not planning pregnancy, contraception should be discussed, while women seeking pregnancy benefit from preconception consultation with maternal–fetal medicine, genetics specialists, and a dedicated CF team due to elevated maternal morbidity.
Importantly, breastfeeding is possible on CFTR modulators , though infants should be monitored for drug transfer effects. Single-gene noninvasive prenatal testing (sgNIPT) is emerging as a valuable tool for detecting fetal CF, and early data suggest that…
