Promethazine a phenothiazine derivative is structurally different from phenothiazine with similar and some different effects. phenothiazine itself a pioneer drug and its derivatives revolutionzed psychiatry. Uses of promethazine: First line antihistaminic(antagonist of h1 receptors). As a sedative, preoperative sedation. To counteract post narcotic nausea and vomiting. Prophylactic to motion or sea sickness alone or with ephedrine. To treat hyperemesis gravidarum.
Previously as antipsychotic agent, use discontinued as it is having 1/10 effect of chlopromazine. Side effects includes: Dyskinesia. Confusion in elderly patients. Drowsiness,diziness and fatigue. Dry mouth(anticholinergic effect). Respiratory depression more common below 2 years of age and some sleep apnoea. Convulsions and some time neuroleptic malignant syndrome (hyperpyrexia,hypotension and stiffness) Should be avoided in…
