A rare case report describes osteochondromatous metaplasia of the breast in a 60-year-old woman presenting with a palpable lump. Histopathology revealed mature bone and cartilage with enchondral ossification in fibrocollagenous stroma, but no atypia or mitoses. Immunohistochemistry was SATB2 positive (osteoblastic differentiation) and pancytokeratin negative , effectively excluding epithelial malignancy.
This underscores the importance of meticulous histopathological and immunohistochemical evaluation to prevent misdiagnosis and unnecessary radical treatment in such rare, benign breast lesions. To read more ; Click here How would you approach a suspicious breast lump with rare histology? A) Always proceed with excision biopsy for confirmation B) Rely on imaging and core needle biopsy first C) Include immunohistochemistry early to rule out malignancy D) Consider multidisciplinary…
