Mycosis fungoides (MF) and Sézary syndrome (SS) are rare cutaneous T-cell lymphomas associated with high mortality, particularly due to lymphoma and infections. While some patients experience slow disease progression, others require early systemic treatment or hospitalization, indicating more severe forms. To assess long-term outcomes, a study has analyzed data from 643 patients, comparing them to 6,420 matched controls to evaluate overall and cause-specific mortality linked to disease severity. The study found that patients with mycosis fungoides or Sézary syndrome had a shorter median survival (14.2 vs.
16.6 years) compared to matched controls. All-cause mortality was significantly higher, especially from lymphoma (aHR 179.76) and infections (aHR 2.78). Those with severe disease had a median survival of just 4.5 years. Lymphoma-related 5-year mortality was 29.2% in severe cases versus…
