Mild cognitive impairment is increasingly recognized as a barrier to adherence and survival in chronic heart failure, yet its biological underpinnings remain underexplored. In a cohort of 952 CHF patients, brain perfusion SPECT identified regional cerebral blood flow (rCBF) abnormalities in nearly one-quarter of individuals. Those with rCBF deficits showed higher rates of atrial fibrillation, hypoalbuminemia, and adverse cardiac events, with survival analyses confirming rCBF abnormality as an independent predictor of prognosis. These findings suggest that cerebral perfusion imaging may provide a powerful, non-cardiac biomarker for refining risk stratification in CHF management.
The journal has the full story. Read it here Does this change how you define high-risk patients in daily practice?
