Certain antihypertensive drug classes are contraindicated in pregnancy because they can disrupt the fetal renin–angiotensin system, which is crucial for normal kidney development and amniotic fluid regulation. Exposure to these agents, particularly in the second and third trimesters, may result in fetal renal dysfunction, oligohydramnios, growth restriction, and other serious neonatal complications. Careful selection of blood pressure medications is therefore essential in pregnant patients to minimize fetal risk.
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