History A 24-year-old man presents to his general practitioner (GP) with a fever. This has been present on and off for 3 days. On the first day he felt a little shaky, but by the third day he felt very unwell with the fever and had a feeling of intense cold with generalized shaking at the same time. He felt very sweaty. The whole episode lasted for 2.5 h, and he felt drained and unwell afterwards. He had lost his appetite. There is a previous history of hepatitis 4 years earlier, and he had glandular fever at the age of 18 years.

He smokes 15–20 cigarettes each day and occasionally smokes marijuana. He denies any intravenous drug abuse. He drinks around 14 units of alcohol each week. He has taken no other medication except for malaria prophylaxis. He denies any homosexual contacts. He has had a number of heterosexual contacts each year but says that all had been with protected…