Ulcerative colitis is a chronic inflammatory condition characterized by relapsing and remitting episodes of inflammation limited to the mucosal layer of the colon. It almost invariably involves the rectum, and may extend to involve other portions of the colon. This article discusses the management of two major types of ulcerative colitis namely severe and fulminant ulcerative colitis.

Initial evaluation for patients presented with symptoms of ulcerative colitis laboratory studies such as blood counts, liver tests, measurement of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), stool studies to rule out an infectious colitis, and a limited evaluation of the colon with flexible sigmoidoscopy to confirm the presence, severity, and extent of inflammation, and to obtain biopsies to exclude the presence of an infection (eg, cytomegalovirus). Severe Ulcerative Colitis This…