This large UK Biobank cohort study evaluated nearly 4000 individuals carrying cardiomyopathy-associated genetic variants but without clinical phenotype (G+P−) to examine the cardiovascular impact of moderate to vigorous physical activity (MVPA). Over a median follow-up of 8 years, higher MVPA was consistently linked to reduced incidence of atrial fibrillation, heart failure, stroke, myocardial infarction, and even future cardiomyopathy in these carriers. Importantly, MVPA did not increase the risk of malignant ventricular arrhythmias—a long-standing concern in cardiomyopathy genetics.
Cardiac MRI findings showed that the structural adaptations in active G+P− carriers mirrored physiological remodeling seen in noncarriers, supporting the concept of benign, exercise-induced changes. Collectively, these findings reinforce current guideline-based MVPA recommendations as appropriate and safe…
