Heart Failure with Preserved Ejection Fraction (HFpEF) remains an underrecognized yet clinically devastating phenotype in India. This comprehensive review by Gupta et al. highlights that nearly one-third of Indian patients hospitalized with acute HF fall within the HFpEF spectrum—despite a seemingly “normal” EF ≥ 50%. The article delves into pathophysiologic heterogeneity, diagnostic challenges, and the growing role of natriuretic peptides, imaging markers, and invasive hemodynamics in accurate phenotyping.
It further contextualizes the latest ACC and ESC guideline updates, detailing the evolving role of SGLT2 inhibitors, MRAs, ARNI, and ARBs in evidence-based therapy. Importantly, the authors outline India-specific care pathways and referral algorithms, underscoring an urgent need for structured HFpEF programs in tertiary care. Read the full article in Journal of Indian College of…
