A 35-year-old woman with a history of severe, persistent asthma presented with worsening cough, wheezing, and dyspnea. She reported that her cough produces thick, brown sputum and has not improved despite treatment with moxifloxacin 400 mg by mouth daily for the past 21 days. Examination Pulmonary-function testing demonstrates an FVC of 3.25 liters (predicted value is 3.20 liters), an FEV 1 of 1.4 liters (predicted is 2.5), and an FEV 1 /FVC ratio of 0.43 (predicted is 0.80). Laboratory testing reveals an absolute eosinophil count of 1200 per mm 3 (reference range, 0-350) and a serum immunoglobulin E level of 800 IU/mL (10–179).
CT of the chest shows central bronchiectasis. What is the most likely diagnosis? *This case is from Docplexus Editorial Team for educative purpose only Source: NEJM The correct answer is posted in the comments section!
