Hands are the first body part to come into contact with objects and substances from our environment. They are frequently the site of exposure to allergens, irritants, and infectious agents. Hence, the palms have a thick keratin layer, a high concentration of sweat glands, Meissner's corpuscles, and other mechanoreceptors. This article provides a quick checklist of to determine the differential diagnosis of the diseases of hands.

Anatomical location of the hands exposes them to various allergens, irritants, and infectious agents. This concept is central to the transmission of pathogens and development of certain dermatological conditions. Although digits are at the distant location, the neurovascular supply of hands predisposes them to neuropathies, ischemic insults, and vasculitis. More sun exposure compared to other centrally located body structures subjecting them to photodermatoses…