Nanoengineers from the University of California, San Diego, have developed a novel and more effective method for delivering messenger RNA into the cells. The researchers used nanoparticles that mimic the flu virus, a natural vehicle for delivering genetic information like RNA inside the cells, to package mRNA. Genetic engineering has been used to create cell membranes enriched with specific surface markers, allowing researchers to modify the functionality of cell membrane-coated nano-formulations with more precision.
Complex surface proteins that are difficult to include using traditional synthetic methods can now be added to the nanoparticles. In this study, researchers developed a cell membrane-coated nanoparticle expressing surface hemagglutinin (HA) , resulting in a nanocarrier with virus-like endosomal escape capabilities and improved cytosolic distribution. Hemagglutinin on the…
