Malignancies of the liver are known to rarely cause acute liver failure. We describe a rare primary malignancy of the liver presenting with acute liver failure. A 53-year-old housewife presented with history of fever, anorexia, and abdominal distension of 2 weeks duration. She was well prior to the onset of these symptoms.
She gave history of being treated for carcinoma breast (infiltrating ductal carcinoma of the breast) five years back with surgery (modified radical mastectomy) and chemotherapy (Paclitaxel-based regimen with Tamoxifen). She denied any chest pain, abdominal pain, vomiting, and diarrhea, blood in stools, night sweats and weight loss. Clinically she had pallor and massive firm hepatomegaly, palpable up to the right iliac fossa. There was no evidence of lymphadenopathy or stigmata of chronic liver disease.
