A new study clearly demonstrated the influence of age and sex of donors and recipients in kidney graft success. Age and sex-based personalized immune-suppressant therapies were suggested by the researchers as they pointed out the critical role of sex hormones regarding immune-reactivity in transplant recipients. Introduction: Patients with End-Stage Renal Disease, where the kidneys have lost about 90% of their normal functionality, are often required to undergo kidney grafting (transplantation).
Several factors including diabetes, polycystic kidney disease, chronic glomerulonephritis, chronic uncontrolled high blood pressure can cause end-stage renal disease. A healthy kidney is transplanted to a recipient from a deceased or living related/ unrelated donor. However, major complications may still arise after a transplantation, such as- hyperacute, acute or chronic transplant rejection,…
