Oxidative stress plays a key role in the pathogenesis of alcoholic liver disease (ALD). This study centred focus on Vitamin E deficiency that is consistent in ALD cases, thereby proposing a robust treatment mode. Alcohol metabolism includes increased synthesis of reduced form of nicotinamide adenine dinucleotide (NAD) hydrogen and suppression of mitochondrial β oxidation and increased lipid peroxidation in liver. This liberates oxygen-free radicals and decrease in mitochondrial glutathione and S-adenosyl-L-methionine levels, thus depleting the endogenous antioxidant capabilities.
Alcoholics with cirrhosis frequently have low vitamin E levels in the liver. This gains importance with the fact that Vitamin E deficiency leads to increased liver vulnerability to alcohol. Vitamin E supplementation to standard treatment showed improvement in liver function parameters and prognostic indicators.…
