Beyond SCLC and Non-small cell lung cancer we have moved into so many subtypes. For clinical purposes main types are adenocarcinoma and squamous cell with diff therapeutic approaches and results. Early detection for high risk persons like smokers with high dose CT is accepted as early stage resections offers best prognosis till date. Inoperable tumors if still localized can be managed by chemoradiation. The large % are detected in stage III or IV Conventional chemotherapy has limitations.
Alimta or pemetrexed came around 2004 with Cisplatin is a potent combo. Several other molecules and chemo regimes exist in first second and even third line but still advanced lung cancer prognosis is dismal. Till molecular targeted therapy burst into oncology in early 2000 s. To find driver mutations and block them to hinder tumour progress not hurting normal cells is what comes in dreams for…
