INTRODUCTION Prokinetic drugs are drugs that enhance gastrointestinal motility mainly by acting on various receptors. Myenteric plexus interneurons containing (CGRP) i.e. Calcitonin Gene-Related Peptide is important in controlling the peristaltic reflex promoting the release of excitatory mediators proximally and inhibitory mediators distally. Excitatory muscle activity is promoted by enteric interneurons that release vasoactive intestinal peptides, nitric oxide, and ATP. Motilin stimulates excitatory neurons or muscle cells directly. Dopamine decreases the intensity of esophageal and gastric contraction.
There are 14 serotonin receptor subtypes. But drug development for GIT application focuses on 5-HT3 receptor antagonists and 5-HT4 receptor agonists. Metoclopramide and cisapride are substituted benzamides. Domperidone is a butyrophenone. The action of all three agents is mediated…
