Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder that affects 800-1000 people. It accounts for 5-10% of patients with renal replacement therapy. In adults, it is correlated with polycystic liver disease (PCLD) and other gastrointestinal symptoms. This article discusses the clinical presentation of the disease. Introduction The most severe type of polycystic kidney disease (PKD) is the ADPKD, which is typically an adult-onset, multisystemic disease.
It is characterized by a slow and progressive enlargement of kidneys followed by renal failure by the age of 50 years. The enlargement of kidneys is due to the development of cysts which can originate from all the areas of the kidney; however, they are mainly found in the distal regions and the collecting duct. ADPKD shows both renal as well as extrarenal manifestations. Over the decades, ADPKD in adults has…
