Chronic pelvic pain associated with endometriosis remains difficult to treat, as symptoms often persist despite surgery and hormonal therapy, and emerging approaches such as intramuscular botulinum toxin injections have been proposed to reduce both pelvic floor muscle spasm and pain neurotransmission; however, robust clinical evidence in this specific population remains limited. To address this gap, a study evaluated whether onabotulinumtoxinA injections into painful pelvic floor muscles could improve pain and spasm outcomes compared with saline placebo in 29 women with endometriosis -associated chronic pelvic pain and pelvic floor hypertonia.
The study found that at 1 month, a significantly greater proportion of women receiving botulinum toxin reported clinical benefit compared with placebo (73% vs 29%), along with greater magnitude and longer duration of pain relief. Women with at…
