A study conducted by a group of American researchers, published in The Lancet Neurology, found that blood tests done on the same day of traumatic brain injury (TBI) to assess two protein biomarkers can predict death or disability in the affected patients. Higher values of the protein biomarkers, glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1), are associated with TBI. Therefore, researchers evaluated if these proteins, GFAP, found in the glial cells, and UCH-L1, found in neurons, can serve as biomarkers, aiding clinicians in making early decisions on treating TBI.
The Glasgow Coma Scale (GCS) was used to determine the area under the curve (AUC) for nearly 1700 patients. It was found that the GCS score of 3-12 for GFAP and UCH-L1 biomarkers contributed the most in providing prognostic information for the patients . The GFAP and UCH-L1 biomarkers…
