Intramuscular mRNA vaccines against SARS-CoV-2 exponentially increase the systemic production of virus-specific IgG and IgA antibodies. However, its effect on antibody production or neutralizing virus within the nasal mucosa is unknown. To address this critical knowledge gap, researchers analyzed immune responses in 29 healthy participants before and after mRNA vaccination from their serum and nasal epithelial lining fluid samples.
SARS-CoV-2 mRNA vaccination induced systemic and intranasal immune response via the production of neutralizing antibodies , and the nasal antibodies exhibited higher neutralization capacity against the receptor binding domain than serum antibodies . In addition, IgG antibodies exhibited higher spike 1 binding specificity than IgA both in serum and nasal mucosa. The mRNA-1273 vaccine exhibited higher concentrations of SARS-CoV-2 specific IgG and IgA antibodies…
