It is well known that the commonly used antifungal drug, ketoconazole, is an endocrine disruptor that causes reversible suppression of adrenal and gonadal steroidogenesis and displaces dihydrotestosterone (DHT) from its receptor. However, there is insufficient evidence for endocrine dysfunction due to nystatin, another commonly used antifungal drug, although few studies have reported hypospadias in males exposed to nystatin in utero.
This article summarizes a case report of severe fetal undervirilization and multiple steroidogenic abnormalities due to intrauterine exposure to nystatin in a 46XY infant who was referred for specialized treatment at the age of five weeks. The case Patient’s details: A five-week-old male neonate of West African origin, born to consanguineous parents Reason for the referral: Severe genital undervirilization with no musculoskeletal abnormalities Medical…
