It is evident that there is a strong association between type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD ). Even though the overall CVD burden has been reduced over the last decade, this is only partially true in the diabetic patients. Despite clear advances in the prevention and treatment of CVD, the impact of T2DM on CVD outcome remains significant and continues to escalate, obesity being the major causative factor worldwide.
Data accumulated over the last decade, strongly suggest that the risk of macrovascular complications increases with the severity of abnormality of blood glucose, indicating that the relation between metabolic disturbances and vascular damage is approximately linear. However, the relation between glucose-lowering approaches and CVD is much more complex than is the case with other cardiovascular (CV) risk factors. Although HbA1c is a reliable marker…
