It is always challenging to strike a balance between the benefits and the complications possible due to the thrombolytic therapy initiated after acute stroke. So far, several clinical trials and large cohort studies have studied this topic by including various possibilities. In this regard, the article provides a checklist for the thrombolytic therapy and some suggestions for secondary stroke prevention based on the recommendations derived from the article published in the well-known journal. The main goal of acute ischemic stroke therapy is restoring perfusion.

The early interventions are aimed at minimizing neurological impairment, long-term disability, and stroke-related mortality. Reperfusion can be achieved through administration of thrombolytic agents. As the decision process of initiating a pharmacotherapy, there are various factors one needs to consider. Hence, guidelines are…