Over recent decades, endometriosis has been associated with the risk of several chronic diseases, such as cancer, autoimmune diseases, asthma or allergic manifestations, and cardiovascular diseases. Because the underlying mechanisms for these relations are not known, understanding the comorbidities can be effective for management of endometriosis. Risk factors: Contraception: Women taking OCs have regular menstrual flow and generally experience a greater number of flows over 1 year than women not taking OCs. Also, Oral contraceptives (OCs) contain progestins that may counteract the effect of estrogens in endometriosis.
Family history: The first-degree relatives of affected women are at three- to the nine-fold higher risk of developing the disease. Coffee intake: Caffeine has been suggested to affect the hepatic production of SHBG that reduces bioavailable testosterone. Caffeine also…
