We have HER2 positive MBC with rib only metastasis diagnosed in 2011. HER2 was reported as IHC 3+ by a private pathology laboratory. She was treated with chemotherapy and trastuzumab. She was on hormonal therapy. After 4.5 years she developed multiple bony metastasis with PET-CT suggestive of small lung nodules.
Lesions were not biopsiable so her based chemotherapy was started. In view of the good biology of disease, HER2 was rechecked at the institute with the help of IHC and FISH. It was found to be negative. Now what should be the management? Shall we continue anti-HER treatment?
