Hypertension is associated with reduced bone mineral density and increased risk of fragility fracture in adults. A recent study on a murine model has assessed the potential effects of hypertension , aging , and pro-inflammatory immune cells in the bone marrow on bone strength and its microstructure. Study design Findings in the young mice with hypertension compared to those without hypertension Significantly reduced bone volume fraction (24%) Reduced thickness of the trabecular bone located at the end of long bones (18%) Reduced estimated failure force (34%) Increased inflammatory signaling molecules suggestive of inflammation A reduction in bone quality similar to that of the hypertensive young mice was seen in older mice with or without hypertension.
The study results suggest that high blood pressure alters the bone remodeling process, leading to bone loss. In addition, the findings…
