Systemic corticosteroids adversely affect skeletal growth and development in children as these agents directly interfere with osteoclast and osteoblast functioning. This results in decreased bone formation, increased resorption, and loss of bone calcium. However, these results are not well-established with inhaled corticosteroids (ICSs).
Moreover, inhaled corticosteroids are widely used for the treatment of mild persistent asthma in children. Thus, research suggests that ICSs may have adverse effects on skeletal growth and development. Source: JAMA Pediatrics
