Author: Deep Dutta, Lakshmi Nagendra, Harish BG, Meha Sharma et al. No meta‑analysis has analysed role of cagrilintide as weight‑loss medication in obese individuals. Electronic databases were searched for RCTs involving obese individuals receiving cagrilintide or cagrilintide‑2.4 mg with semaglutide‑2.4 mg combination (Cagrisema) compared to placebo/active comparator. Primary outcomes were changes in body weight; secondary outcomes were alterations in glycemia, lipids, and adverse events.
From 678 articles, data from 3 RCTs involving 430 individuals were analysed. At 20–32 weeks, patients receiving Cagrisema weekly had significantly greater percentage [mean difference (MD)−9.07% (95%CI: −11.91, −6.23); P < 0.00001;I2 = 96%] and absolute [MD‑9.11 kg (95%CI: −12.84, −5.39); P < 0.00001; I2 = 98%] weight‑loss, compared to semaglutide 2.4 mg weekly. At 26–32 weeks, cagrilintide 2.4 mg…
