Background: Atypical antipsychotic agents (AAP) alleviate the symptoms of severe mental healthdisorders, such as schizophrenia, by antagonizing dopamine and serotonin receptors. Recently, AAPhave also been shown to exhibit immunomodulatory properties in the central nervous system (CNS). Objective: Building on research which demonstrated the ability of the AAP risperidone and clozapine tomodify the disease course of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), we aimed to more fully investigate the potential of clozapine as a possibletreatment for MS.
Results: We report that orally administered clozapine significantly reduced the disease severity of EAE in a dose-dependent manner and was effective when administered prophylactically and therapeutically. In comparison to risperidone, quetiapine, and olanzapine, clozapine was the best at…
