If a newborn is presented with a stained diaper with dark yellow urine and detected with jaundice, what is the immediate diagnosis by a physician? It can be neonatal cholestasis. There is a need to create better awareness among the pediatricians, obstetricians, and primary care physicians on early recognition, prompt evaluation and treatment for the disease as a late referral can even lead to the need of liver transplant. Among different etiology obstructive cause warrants most attention as it needs immediate surgical intervention .
Neonatal cholestasis (NC) is defined as conjugated hyperbilirubinemia occurring in the newborn as a consequence of diminished bile flow. Conjugated hyperbilirubinemia in a neonate is defined as a serum direct/conjugated bilirubin concentration greater than 1.0 mg/dL if the total serum bilirubin (TSB) is 5.0 mg/dL. Etiology Although there are multiple causes…
