The development of allergic diseases has been attributed to complex interactions between environmental factors and genetic factors. There is an increasing evidence that such environmental factors play a critical role in the regulation of the immune response that is associated with allergic diseases, especially in genetically susceptible individuals. This article reviews the environmental factors and genetic factors associated with the development of allergic diseases.
Of the many possible environmental factors, most research has focused on the most commonly encountered environmental factors, such as air pollution and environmental microbiota in combination with climate change. Recently, there has been a dramatic increase in the prevalence of noncommunicable diseases (NCDs), such as cardiovascular disease, metabolic disease, cancer, chronic obstructive pulmonary disease, inflammatory…
