Individuals diagnosed with diabetes mellitus (DM) are more susceptible to dry eye disease (DED).1 The processes behind this phenomenon are still unknown. The ocular surface microbiota (OSM) of DED patients and healthy individuals differ considerably, which raises the possibility that OSM dysbiosis plays a role in the etiology of DED.1 The ocular surface microbiome emerges as a key player in the intricate interplay between DM and DED.2