The cornerstone treatment for DED is artificial tears.1 Artificial tears rely extensively on polymers, which set the formulations' viscosity and aid in tear-film stabilization by extending the lubricant's duration on the ocular surface, where it can improve comfort and vision.1 Combination polymer-based artificial tears are advantageous to single-polymer-based artificial tears for ocular lubrication, retention, and synergistic effects on the ocular surface.1 Two major polymers in lubricants eyedrops include HPG and HA.