A drug when administered in the body goes through several chemical and metabolic changes. These changes reduce the availability of the drug and thus reduce the intensity of its action in the body. Hence choosing a correct route of drug administration is very important for the drug efficacy and to obtain maximum benefit. This article discusses the gastrointestinal routes of administration and associated pros and cons. Bioavailability of the drug is an important parameter.
By definition bioavailability is "the proportion of the drug that is delivered to its site of action in the body". In short, it's the final amount which remained after circulation and absorption (when given orally). There are multiple parameters which determine the route of administration, Drug properties: Solid, liquid, or gas. Chemical properties (pH, solubility etc) Rate and extent of absorption at the administration…
