Transplanting gut microbiota from GDM patients into antibiotic-pretreated pregnant mice triggers glucose intolerance, with 16S rRNA revealing reduced Lachnospiraceae_FCS020_group alongside elevated Akkermansia , Faecalibaculum , and Bilophila . This dysbiosis downregulates intestinal barrier Claudin-1, elevates serum LPS, resistin, and MMP-9, while metabolomics shows depleted primary bile acids (CA, CDCA) and secondary DCA. Faecalibaculum positively correlates with DCA/CDCA/resistin, while bile acids inversely link to insulin resistance and resistin drives glucose dysregulation, positioning microbiota-driven bile acid shifts and low-grade inflammation as modifiable GDM drivers impacting fetal health.
Reshape maternal microbiomes—secure healthier generations! To read more Click Here ##Reference## Huang J, Zhang Y, Zheng W, Li G. Gut microbiota contributes to gestational diabetes mellitus…
