Measurement of serum cobalamin and folate forms a considerable proportion of the routine laboratory findings. The evidence-based guideline recommendations provide proper advice which can lead to improvement in diagnosis and clinical practice. These guidelines for the diagnosis and treatment of Cobalamin and Folate disorders outline the effective approaches for effective management of cobalamin and folate deficiencies. The biochemical pathways of cobalamin and folate are closely intertwined.
With patients showing similar clinical features for both deficiencies, assessment of cobalamin and folate status is usually performed concurrently. Recent clinical findings report that, in the presence of true cobalamin deficiency, the serum folate is often normal or can be elevated. However, a low serum cobalamin level may be found in the presence of folate deficiency. Cobalamin deficiency The…
