A study investigated the association between the gut microbiome and the risk of type 2 diabetes (T2D) in 4,685 individuals with a mean age of 73.9 years. During a median follow-up of 5.3 years, shotgun metagenomic analysis identified six species associated with an increased risk of T2D: Desulfovibrio piger, Alistipes communis, Alistipes finegoldii, Akkermansia muciniphila, Ruminococcus gnavus, and GGB3614_SGB4886 (Lachnospiraceae) . Three species, including Erysipelotrichaceae bacterium, Coprococcus catus, and Clostridia unclassified SGB6317 , were associated with a lower risk of T2D. A dietary analysis found that the association between A.
muciniphila and T2D risk was stronger among participants with low dietary fiber intake . However, higher dietary fiber intake was linked to lower A. muciniphila abundance. Among the 103 gut metabolic modules investigated, asparagine degradation…
