HFpEF-Like Phenotype Is Highly Prevalent in Revascularized CAD, With Obesity Emerging as the Primary Driver

A retrospective analysis published in Clinical Cardiology evaluated the prevalence and clinical correlates of a heart failure with preserved ejection fraction (HFpEF)-like phenotype among 435 patients with revascularized coronary artery disease (CAD) and preserved left ventricular ejection fraction (LVEF) from the RICCADSA cohort. The HFpEF-like phenotype was defined by the presence of at least two of the following: elevated filling pressures (E/e′ ≥15), left atrial enlargement, increased left ventricular mass index, pulmonary artery systolic pressure ≥35 mmHg, or NT-proBNP ≥125 pg/mL. Obstructive sleep apnea (OSA) was defined as an apnea–hypopnea index (AHI) of ≥15 events/hour.

Overall, 69.9% of patients met the HFpEF-like criteria. Multivariable analyses identified older age and obesity as independent predictors of the phenotype, whereas categorically defined OSA was not…