This opinion piece broadens the concept of insulin resistance from a defect confined to muscle, liver, and adipose tissue to a systems-level disorder that also affects the brain and blood–brain barrier. It synthesizes molecular, cellular, and neuroimaging data showing that brain insulin resistance contributes to cognitive dysfunction and neurodegenerative disease, including Alzheimer’s, while interacting bidirectionally with peripheral insulin resistance. The authors argue for an integrated framework that leverages multi-omics, imaging, and big-data approaches to detect early brain–peripheral insulin resistance signatures and to design interventions that simultaneously target metabolic and neurodegenerative pathways.
To read more click here ##Reference## Chen, Wenqiang et al. Expanding the understanding of insulin resistance in brain and periphery. Trends in Endocrinology & Metabolism.…
