How Can Codeine Cause Depression of the Respiratory System?

Codeine is a narcotic pain reliever and cough suppressant. It shows a similar drug action to morphine and hydrocodone. Codeine is used as a central analgesic, sedative, antinociceptive, and antiperistaltic. Its mechanism of action includes binding to the opioid receptors, thereby inhibiting pain.

Codeine may cause drowsiness, and respiratory depression, reduce intestinal motility and affect blood pressure. Do you know which of the following receptor is activated as an effect of codeine, causing respiratory system depression? Mu-opioid receptors Delta-opioid receptors Kappa-opioid receptors *This question is from the Editorial Team of Docplexus and is meant for educative purposes only.