Insulin pumps reduce the risk of acute diabetes complications and improve glycemic control compared to insulin injections. However, the effects of hybrid closed-loop insulin therapy on diabetes complications in type 1 diabetes (T1D) patients remain underexplored. To address this gap, researchers have compared the effectiveness of hybrid closed-loop insulin therapy with open-loop insulin pump therapy in young T1D patients (n = 13,922; median age – 13.2 years). The study found that closed-loop therapy improved glycemic control, resulting in lower HbA1c levels (7.34% vs. 7.50%), increased time in the target glucose range of 3.9-10.0 mmol/L (64% vs.
52%), and a reduced rate of hypoglycemic coma (0.62 vs. 0.91 per 100 patient-years) compared to open-loop therapy. However, ketoacidosis rates were higher with closed-loop therapy (1.74 vs. 0.96 per 100 patient-years), particularly in patients…
