Preoperative Radiotherapy Reimagined: Can Fewer Fractions Deliver More? Conventional preoperative radiotherapy for soft tissue sarcomas improves local control but often comes with prolonged treatment schedules and notable wound complications. This institutional study explored whether hypofractionated regimens could offer a shorter, more practical alternative without compromising outcomes. In a prospective cohort of 24 patients , two shortened regimens were evaluated.
All patients completed treatment without interruption, and a strong pathological response was observed in 66.7% of cases. Acute toxicity was largely mild, with no high-grade adverse events reported, although major wound complications occurred in 29.2% of patients. Functional outcomes remained encouraging, with high limb preservation scores, and local control rates reached 100% at both 1- and 2-year follow-up. These findings…
