A 69-year-old man was admitted to the hospital for the evaluation and treatment of neutropenia and anemia. CBC: 1000/µl (Ref. range: 4800 - 10,800/µl) 10% neutrophils (Absolute neutrophi count: 100) Hb: 10.6g/dL (Ref. range: 14-18 g/dL) Bone marrow aspiration: 5% blasts abd 65% promyelocytes. Many promyelocytes Auer rods (refer figure) and mitotic figures.
Fluorescence in situ hybridization showed a translocation involving chromosomes 15 and 17, leading to the production of a fusion protein, promyelocytic leukemia–retinoic acid receptor alpha. Identify the most likely condition from the attached image and laboratory examination. *This case is from Docplexus editorial team for educative purpose only. Source: NEJM Stay connected, the answers will be posted in next 48h!
