Many patients with insulin-dependent diabetes mellitus have an increase in the glomerular filtration rate and renal enlargement early in the course of their disease. Both these changes may be risk factors for the later development of diabetic nephropathy. Sex-based differences in renal segmental resistances do exist in patients with type 1 diabetes (T1D).
Female type 1 diabetes (T1D) patients have higher efferent arteriolar resistance (RE) and filtration fraction (FF) and lower effective renal plasma flow (ERPF) than their male counterparts with no associated sex differences in afferent arteriolar resistance (RA). There is growing evidence that significant sex differences exist in the response of the kidney to injury or diabetic nephropathy. An early hemodynamic abnormality associated with diabetic nephropathy (DN) - would disproportionately affect women with T1D, thereby attenuating…
