Menetrier’s disease is a rare disease that is challenging to diagnose due to its common gastrointestinal presentation, an unknown pathology, and unspecified management strategies. It is progressive in adults and can lead to malignancies if not treated in time. Menetrier’s disease causes rugae (ridges) inside the stomach wall to enlarge due to the overgrowth of mucous cells. These giant mucosal folds lead to excessive mucosal secretion , causing proteins to leak from the blood into the stomach.
This causes hypoproteinemia and diminished acid secretion . It usually affects the proximal part (body and fundus) and spares the distal part (antrum) of the stomach. Menetrier’s disease is also known as hypoproteinemic hypertrophic gastropathy or giant hypertrophic gastritis. Etiology The exact cause of Menetrier’s disease remains unknown; however, researchers believe it to be mostly acquired…
